The Colts and Jaguars have played some close contests since they moved to the AFC South and this NFL week 1odds matchup won’t be any different. Look for the Jaguars to do what they typically do: run the ball down the Colts’ throat and try to hold possession of the ball. But as long as Peyton Manning is healthy and running the show for the Colts, they won’t be losing this season opener.

The Colts are a seven-point favorite in the sportsbook and, considering they dominate this series, why not? All they have to do is slow down Maurice Jones-Drew and pick apart a soft Jags defense. Take it to the house.

WHEN: Sunday, September 13th – 1:00 PM ET
WHERE: Lucas Oil Stadium
SPREAD: Colts -7 
PICK: Colts -7